Process Optimization and Synthesis of 3-(4-Fluorophenyl)-4,5-dihydro- N -[4-(tri- fluoromethyl)phenyl]-4-[5-(trifluoromethyl)-2-pyridyl]-1 H -pyrazole-1-carboxamide
✍ Scribed by Renga, James M.; McLaren, Kevin L.; Ricks, Michael J.
- Book ID
- 119956747
- Publisher
- American Chemical Society
- Year
- 2003
- Tongue
- English
- Weight
- 102 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1083-6160
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📜 SIMILAR VOLUMES
The title compound 3 was obtained during the rearrangement of isoxazol-5-yl hydrazine 1 to 1 -aminopyrazolone 2 at \(115^{\circ}\). X-ray analysis of the corresponding benzylidene derivative allowed us to achieve the structure assignment.
## Abstract magnified image Substituted 4‐(5‐alkyl‐thiazol‐2‐ylmethyl)‐3,4‐dihydro‐2__H__‐1,4‐benzoxazines and 5‐(2,3‐dihydro‐1,4‐benzoxazin‐4‐ylmethyl)‐4‐methyl‐1‐phenyl‐1__H__‐pyrazol‐3‐ylamines were prepared by the reaction of (2,3‐dihydro‐1,4‐benzoxazin‐4‐yl)‐acetic acid methyl ester and some