Automated on-line HPLC-HRGC: Instrumental aspects and application for the determination of heroin metabolites in urine

✍ Scribed by Munari, F. ;Grob, K.

• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: English
• Weight: 388 KB
• Volume: 11
• Category: Article
• ISSN: 0935-6304
• DOI: 10.1002/jhrc.1240110206

✦ Synopsis

It has been suggested that the observed retention of carbonyl compounds could be explained by keto-enol tautomerism, i.e. interactions of surface silanols with aliphatic -OH groups of the enols. We do not find this to be likely, since the tauto-~7 1

[I81 [19]

meric equilibrium very strongly favors the keto form except for P-discarbonyls. Moreover, the chromatograms clearly show different types of results for the aldehydes and ketones than for the alcohols in the test mixtures. If the enol forms were predominant, this would not be the case.