Autologous responses to human leukaemic cells in mixed leucocyte culture

✍ Scribed by Leonie K. Ashman; Denise E. O'Keefe; Christopher A. Juttner; R. G. Toogood; Michael S. Rice

• Book ID: 104660393
• Publisher: Springer-Verlag
• Year: 1986
• Tongue: English
• Weight: 525 KB
• Volume: 22
• Category: Article
• ISSN: 0340-7004
• DOI: 10.1007/bf00199121

✦ Synopsis

Cryopreserved leukaemic blasts and remission non-T cells from 22 patients with acute leukaemia (15 lymphocytic, 7 non-lymphocytic) were tested as stimulators of autologous remission T cells and normal allogeneic T cells in primary and secondary MLC. In most cases the autologous response elicited by leukaemic cells was less than or equal to that elicited by remission non-T cells. However, T cells from 2 patients in long-standing first remission from ANLL displayed greater proliferation in response to leukaemic blasts than to remission non-T cells in both primary and secondary MLC. The results are suggestive of sensitization of these 2 patients to leukaemia-specific antigens, but other possible explanations are discussed.