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Autoimmunity and cystatin SA1 deficiency behind chronic mucocutaneous candidiasis in autoimmune polyendocrine syndrome type 1

✍ Scribed by Lindh, Emma; Brännström, Johan; Jones, Petra; Wermeling, Fredrik; Hässler, Signe; Betterle, Corrado; Garty, Ben Zion; Stridsberg, Mats; Herrmann, Björn; Karlsson, Mikael C.I.; Winqvist, Ola

Book ID: 122504774
Publisher: Elsevier Science
Year: 2013
Tongue: English
Weight: 547 KB
Volume: 42
Category: Article
ISSN: 0896-8411
DOI: 10.1016/j.jaut.2012.10.001

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## Abstract Autoimmune polyendocrine syndrome type 1 (APS‐1) is a multiorgan autoimmune disease caused by mutations in the autoimmune regulator (AIRE) gene. Chronic mucocutaneous candidiasis, hypoparathyroidism and adrenal failure are hallmarks of the disease. The critical mechanisms causing chroni