Tryptophan hydroxylase autoantibodies and intestinal disease in autoimmune polyendocrine syndrome type 1
✍ Scribed by Olov Ekwall; Klas Sjöberg; Rita Mirakian; Fredrik Rorsman; Olle Kämpe
- Book ID
- 117312610
- Publisher
- The Lancet
- Year
- 1999
- Tongue
- English
- Weight
- 27 KB
- Volume
- 354
- Category
- Article
- ISSN
- 0140-6736
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## Abstract Autoimmune polyendocrine syndrome type 1 (APS‐1), also known as Autoimmune Polyendocrinopathy Candidiasis and Ectodermal Dysplasia (APECD) is a disorder caused by mutations in the autoimmune regulator (__AIRE__) gene. In some APS‐1 patients, significant pulmonary disease is observed. Au
## Abstract Autoimmune polyendocrine syndrome type 1 (APS‐1) is a multiorgan autoimmune disease caused by mutations in the autoimmune regulator (AIRE) gene. Chronic mucocutaneous candidiasis, hypoparathyroidism and adrenal failure are hallmarks of the disease. The critical mechanisms causing chroni