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Autoimmune disorders: a concept of treatment based on mechanisms of disease

โœ Scribed by Miescher, Peter A. ;Zavota, Laura ;Ossandon, Alejandra ;Lagana, Bruno


Publisher
Springer
Year
2003
Tongue
English
Weight
387 KB
Volume
25
Category
Article
ISSN
0344-4325

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ral tolerance describes the observation that a state of hyporesponsiveness follows immunization with a previously fed protein. It was first described in 1911 when Wells fed hen egg proteins to guinea-pigs and found them resistant to anaphylaxis when challengedL In 1946, Chase fed guinea-pigs the con

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Oral tolerance is the phenomenon of systemic, antigen specific, immunological hyporesponsiveness that results from oral administration of a protein. The mechanism by which tolerance is generated depends on the amount of antigen administered; low doses favor induction of regulatory T cells while high