𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Autocrine TGFα expression in the regulation of initiation of human colon carcinoma growth

✍ Scribed by Degeng Wang; Wenhui Li; Wen Jiang; Lisa E. Humphrey; Gillian M. Howell; Michael G. Brattain

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
258 KB
Volume
177
Category
Article
ISSN
0021-9541

No coin nor oath required. For personal study only.

✦ Synopsis

Previously, we reported that unaggressive, growth factor-dependent FET human colon carcinoma cells downregulated their transforming growth factor alpha (TGFa) expression in a quiescent state (G 0 /G 1 ) induced by growth factor and nutrient deprivation (Mulder, 1991, Cancer Res.,

📜 SIMILAR VOLUMES

Expression of TGFα autocrine activity in
Expression of TGFα autocrine activity in human colon carcinoma CBS cells is autoregulated and independent of exogenous epidermal growth factor
✍ Dianhua Jiang; Jiurong Liang; Lisa E. Humphrey; Haisu Yang; Michael G. Brattain 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 281 KB 👁 1 views

Autocrine transforming growth factor a (TGFa) activity and control mechanisms for its expression were examined in a representative clonal isolate (CBS4) of a well-differentiated human colon carcinoma cell line designated CBS. CBS4 cells expressed TGFa and its receptor, epidermal growth factor recept

CD44s expression in human colon carcinom
CD44s expression in human colon carcinomas influences growth of liver metastases
✍ Seung Ho Choi; Kazuhisa Takahashi; Hiroshi Eto; Sam S. Yoon; Kenneth K. Tanabe 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 65 KB 👁 2 views

CD44 is a family of cell-surface adhesion molecules which exist in several isoforms arising from mRNA alternative. Malignant transformation of colonic mucosa is associated with alterations in CD44 expression, which result in up-regulation of high-molecular-weight CD44 isoforms and down-regulation of

Amphiregulin and hepatocyte-derived extr
Amphiregulin and hepatocyte-derived extracellular matrix regulate proliferation and autocrine growth factor expression in colon cancer cell lines of varying liver-colonizing capability
✍ Isabel Zvibel; Shlomo Brill; Zamir Halpern; Moshe Papa 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 169 KB 👁 2 views

We studied the effect of two members of the epidermal growth factor (EGF) family-amphiregulin and heparin-binding EGF-like growth factor (HB-EGF)-on cell proliferation, growth factor and growth factor receptor expression, and cell differentiation in two human colon cell lines of varying liver-coloni

Differential expression of angiopoietin-
Differential expression of angiopoietin-1 and angiopoietin-2 in colon carcinoma : A possible mechanism for the initiation of angiogenesis
✍ Syed A. Ahmad; Wenbiao Liu; Young D. Jung; Fan Fan; Niels Reinmuth; Corazon D. B 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 500 KB

## Background: Angiopoietin-1 (ang-1) and angiopoietin-2 (ang-2) are important regulators of endothelial cell (ec) survival. current models suggest that an increase in ang-2 expression in ecs leads to the initiation of angiogenesis. the authors hypothesized that the imbalance of ang-1 and ang-2 act

Altered transcriptional regulation of th
Altered transcriptional regulation of the insulin-like growth factor 2 gene in human hepatocellular carcinoma
✍ Kosaku Uchida; Masashi Kondo; Shin Takeda; Hirotaka Osada; Toshitada Takahashi; 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 158 KB 👁 2 views

The insulin-like growth factor 2 (IGF2) gene is regulated in a complex manner, involving developmentally regulated use of four different promoters as well as transcriptional repression of the maternal allele due to genomic imprinting. It has been well documented that liver is an exceptional organ in