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Autocrine growth hormone production prevents apoptosis and inhibits differentiation in C2C12 myoblasts

✍ Scribed by Haniaa Bouzinba Segard; Stéphanie Moulin; Stéphanie Boumard; Catherine Augier de Crémiers; Paul A. Kelly; Joëlle Finidori


Book ID
114283804
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
471 KB
Volume
15
Category
Article
ISSN
0898-6568

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## Abstract IGF‐I and IGF‐II are thought to be unique in their ability to promote muscle cell differentiation. Murine C2 myoblasts differentiate when placed into low serum media (LSM), accompanied by increased IGF‐II and IGF binding protein‐5 (IGFBP‐5) production. Addition of 20 ng/ml TNFα on trans