## AMAs are detectable by indirect immunofluorescence (IF) We examined the clinical usefulness of measurements on tissue substrates in 93% to 99% of patients with PBC, but of antimitochondrial autoantibodies (AMA) in prethis method also detects AMAs of differing specificities in dicting disease pr
Autoantibody IgG subclasses to recombinant antigens and the role of bacterial stimuli in primary biliary cirrhosis
โ Scribed by Toshihiro Kawai; Naomi Hosoya; Yuki Moritoki; Yusuke Kajiyama; Masashi Watanabe; Atsuko Takai; Carlo Selmi; M. Eric Gershwin; Hiroshi Miyakawa; Kentaro Kikuchi
- Book ID
- 118088158
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 224 KB
- Volume
- 39
- Category
- Article
- ISSN
- 1386-6346
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๐ SIMILAR VOLUMES
The appearance of autoantibodies against mitochondria in patients with primary biliary cirrhosis has been known for more than 25 yr. In the past, based on the biochemical complexity of the mitochondrion and the use of crude extracts for immunodiagnosis, a degree of nonspecificity in assaying for ant
We have previously identified four of the M2 antigens in primary biliary cirrhosis as the E2 components (dihydrolipoamide acyltransferases) of pyruvate dehydrogenase complex, branched-chain 2-0x0 acid dehydrogenase complex and 2-oxoglutarate dehydrogenase complex and the protein X component of pyruv
Autoantibodies against inner mitochondrial membrane proteins are a hallmark of primary biliary cirrhosis. Specifically, these antimitochondrial autoantibodies recognize two polypeptides of approximately 70 and 52 kD, respectively. Although the specificity of antimitochondrial autoantibodies has been