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Autoantibodies to villin occur frequently in IPEX, a severe immune dysregulation, syndrome caused by mutation of FOXP3

✍ Scribed by Ichiro Kobayashi; Mitsuru Kubota; Masafumi Yamada; Hiroshi Tanaka; Shuichi Itoh; Yoji Sasahara; Luke Whitesell; Tadashi Ariga


Book ID
113542002
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
798 KB
Volume
141
Category
Article
ISSN
1090-2341

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The immune dysregulation, polyendocrinop
✍ Ochs, Hans D.; Bennett, Craig L.; Christie, Jacinda; Ramsdell, Fred; Brunkow, Ma πŸ“‚ Article πŸ“… 2001 πŸ› Nature Publishing Group 🌐 English βš– 44 KB

The gene WAS, contained in this interval, was excluded as a candidate for IPEX (refs. 1,2). The scurfy syndrome in mice 3 shares phenotypic features with IPEX and maps to a region of conserved synteny on the mouse X chromosome. Human and mouse FOXP3 were recently identified by positional cloning and