There is evidence that infection by Coxsackie viruses can serve as an environmental "trigger" for insulin-dependent diabetes mellitus (IDDM). This background information is summarized briefly, and the data in the IDDM component of Genetic Analysis Workshop 5 (GAWS) concerning serum antibodies to Cox
Autoantibodies to pancreatic islet cells and insulin in IDDM families: The GAW5 data
β Scribed by Noel K. Maclaren; William J. Riley; David K. McCulloch; Dr. Jerry P. Palmer
- Book ID
- 102224653
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 169 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0741-0395
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β¦ Synopsis
Antibodies to pancreatic islet cells and insulin were studied in the Genetic Analysis Workshop 5 (GAW5) families, as indicators of an autoimmune component of pathogenesis. The rationale for these studies is summarized briefly, and references to the laboratory methods used are provided.
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Key words: restriction fragment length polymorphism (RFLP), insulin gene 5' flanking polymorphism (5' FP), insulm gene 6.0-kb probe, Southern blotting, HLA-DBP band patterns, HLA-DQP band patterns, HLA-DR subtypes I NTROD UCTl ON A principal aim of the insulin-dependent diabetes mellitus (IDDM) comp
Genetic determination as well as prospective analysis of islet cell autoantibodies and autoantibodies to insulin were conducted in a population of 479 first degree relatives of 174 Type 1 (insulin-dependent) diabetic patients. Analysis of HLA haplotypes within families illustrated the high frequency