Autoantibodies to glucose‐6‐phosphate isomerase are elevated in the synovial fluid of rheumatoid arthritis patients
✍ Scribed by Cha, H‐S; Kim, TJ; Kim, J‐Y; Lee, M‐H; Jeon, CH; Kim, J; Bae, E‐K; Ahn, K‐S; Koh, E‐M
- Book ID
- 121280041
- Publisher
- Informa plc
- Year
- 2004
- Tongue
- English
- Weight
- 284 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0300-9742
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To determine whether complement turnover in synovial fluids of patients with rheumatoid arthritis (RA) reflects activation by the classical or alternative pathway, we used novel immunoassays to measure products of complement activation (the membrane attack complex SC5b-9 and the cleavage fragments B
## Abstract ## Objective Arthritis in the K/BxN mouse model results from pathogenic immunoglobulins that recognize glucose‐6‐phosphate isomerase (GPI), a glycolytic enzyme residing in the cytoplasm of all cells. Antibodies directed against GPI can, alone, transfer arthritis to healthy recipients.