Auranofin induces apoptosis and when combined with retinoic acid enhances differentiation of acute promyelocytic leukaemia cells in vitro
β Scribed by I S Kim; J Y Jin; I H Lee; S J Park
- Book ID
- 110008232
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 255 KB
- Volume
- 142
- Category
- Article
- ISSN
- 0007-1188
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The effect of retinoic acid (RA) alone and in combination with cytosine arabinoside (Ara-C) on differentiation of fresh human myeloid leukaemic cells from patients with AML was studied. Cells from six patients: three with acute myelomonocytic leukaemia AMMoL and three with acute monoblastic leukaemi
Treatment of the acute promyelocytic (APL) cell line NB4 with interferon alpha (IFN(alpha)), as well as IFN(beta) and gamma, results in an increased expression of the transcripts coding for retinoic-acid receptor type alpha (RAR(alpha)) and the leukemia-specific retinoic acid receptor PML-RAR. Trans