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Augmentation of natural cell activity in tumor-bearing and normal mice by MVE-2

✍ Scribed by Wladyslaw Budzynski; Michael Chirigos; Eilene Gruys

Publisher
Springer-Verlag
Year
1987
Tongue
English
Weight
578 KB
Volume
24
Category
Article
ISSN
0340-7004

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✦ Synopsis

Mice bearing advanced Lewis lung carcinoma were found to have significantly decreased natural killer (NK) cell activity in spleen and blood. The same pattern of lowered spontaneous NK cell activity was observed in nude mice with advanced human colon carcinoma LS 174 and in C3H mammary tumor virus-positive mice that spontaneously developed mammary adenocarcinomas. Maleic anhydride divinyl ether (MVE-2) usually augments NK cell activity in normal mice. We found that the lower level of spontaneous NK cell activity in tumor-bearing mice could be boosted by a single injection of MVE-2; however, this response was much weaker than that observed in age-matched normal mice. Multiple treatments with MVE-2 which are known to induce hyporesponsiveness to further augmentation of NK cell activity in spleen and blood of normal mice, also produced NK cell hyporesponsiveness in the spleen, bone marrow, and blood of tumor-bearing mice.

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