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Augmentation of natural killer activity by pyran copolymer in mice

✍ Scribed by Angela Santoni; Paolo Puccetti; Carlo Riccardi; Ronald B. Herberman; Enzo Bonmassar

Publisher
John Wiley and Sons
Year
1979
Tongue
French
Weight
549 KB
Volume
24
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Treatment of older mice with pyran copolymer, a known interferon‐inducer, was found to result in a rapid boosting of cell‐mediated cytolytic activity against YAC‐1 tumor target cells. The effector cells were characterized as being non‐adherent and were presumed to be natural killer (NK) cells. Augmentation occurred in various lymphoid organs and was detectable 2–3 days after drug treatment. Differences in the levels of boosted activity among the lymphoid organs resulted when the route of administration was varied. The degree of augmentation was largely independent of the dose of pyran, but did vary among different strains of mice. Augmentation, moreover, was followed by a rapid decline by 5–7 days.

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