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Auer rods in the acute myeloid leukemias: Frequency and methods of demonstration

✍ Scribed by N. C. Jain; C. Cox; J. M. Bennett

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 335 KB
Volume: 5
Category: Article
ISSN: 0278-0232
DOI: 10.1002/hon.2900050306

No coin nor oath required. For personal study only.

✦ Synopsis

One hundred and twenty-five cases of acute myeloid leukemia (AML) were reviewed for the presence of Auer rods by two peroxidase methods. The percentage of Auer rods recognized by Wright-Giemsa (WG) staining was 20.8% but three times higher by peroxidase staining techniques using either benzidine base as a substrate (PO method) or 3,3'-diaminobenzidine as a substrate (DAB method). Both PO and DAB methods were equally sensitive in identifying Auer rods, the higher percentage being in FAB types M2 and M4 and lower in M1, M3, and M5B, with none in M5A. Cell counts of at least 100 cells were as accurate as counting cells up to a total of 1000 consecutive blasts.

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