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Attenuation of IL-2 and tac receptor expression by selective PDE inhibitors in human T-lymphocytes

✍ Scribed by S. Robicsek; D.K. Blanchard; J. Djeu; J.J. Krzanowski; A. Szentivanyi; J.B. Polson


Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
103 KB
Volume
13
Category
Article
ISSN
0192-0561

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Resting human T lymphocytes do not express receptors for interleukin-2, but expression is rapidly induced by exposure to PHA. After maximal expression 2-3 days after stimulation, a progressive decline in receptor number is observed. Receptor expression can be augmented by reexposure to PHA. In this