✦ LIBER ✦

Activators of protein kinase C and 5-azacytidine induce IL-2 receptor expression on human T lymphocytes

✍ Scribed by Joel M. Depper; Warren J. Leonard; Cynthia L. Drogula; Martin Krönke; Thomas A. Waldmann; Warner C. Greene

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 598 KB
Volume: 27
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.240270308

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✦ Synopsis

Resting human T lymphocytes do not express receptors for interleukin-2, but expression is rapidly induced by exposure to PHA. After maximal expression 2-3 days after stimulation, a progressive decline in receptor number is observed. Receptor expression can be augmented by reexposure to PHA. In this study we show that activators of protein kinase C including phorbol diester, phospholipase C, and the diacylglycerol congener diCs also increase IL-2 receptor expression. Moreover, hzacytidine, which inhibits cytosine methyltransferase, and hydroxyurea, which inhibits ribonucleotide reductase, also increased receptor number. These studies demonstrate that IL-2 receptor expression can be altered in vitro, and that IL-2 receptor number, in combination with IL-2 secretion, may contribute to the regulation of IL-2-dependent immune responses.

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