𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Attenuating effect of the monoamine oxidase inhibitor furazolidone on the anti-carcinogenetic effect of cysteamine on gastric carcinogenesis induced by N-methyl-N′-nitro-N-nitrosoguanidine in Wistar rats

✍ Scribed by Masaharu Tatsuta; Hiroyasu Iishi; Miyako Baba; Haruo Taniguchi

Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
513 KB
Volume
48
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

The effect of furazolidone on inhibition by cysteamine of gastric carcinogenesis induced by N-methyl-"-nitro-Nnitrosoguanidine (MNNG) was investigated in inbred Wistar rats. After oral treatment with MNNG for 25 weeks, rats received cystearnine, furazolidone, or both compounds. In week 52, rats treated with cystearnine had a significantly decreased incidence of gastric cancers. Concomitant treatment with furazolidone significantly attenuated the inhibitory effect of cysteamine on gastric carcinogenesis. Administration of furazolidone alone significantly increased the number, but not the incidence, of gastric cancers. The norepinephrine concentration of the antral portion of the gastric wall and the labelling index of the antral mucosa were significantly reduced in rats treated with cystearnine, and significantly higher in rats treated with both compounds than in those treated with cystearnine alone. These findings indicate that the cystearnine-induced inhibition of gastric carcinogenesis is mediated by catecholamines.

📜 SIMILAR VOLUMES

Enhancement by sulpiride of the inhibito
Enhancement by sulpiride of the inhibitory effects of cysteamine on gastric carcinogenesis induced by n-methyl-n'-nitro-n-nitrosoguanidine in wistar rats
✍ Masaharu Tatsuta; Hiroyasu Iishi; Miyako Baba; Akihiko Nakaizumi; Hiroyuki Uehar 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 675 KB

The effects of sulpiride on cysteamine iyhibition of gastric carcinogenesis induced by N-methyl-N -nitro-N-nitrosoguanidine (MNNG) and on the BUdR labelling index of gastric mucosa were investigated in inbred Wistar rats. After 25 weeks of oral treatment with MNNG, rats received one of the following

Effect of ornithine decarboxylase inhibi
Effect of ornithine decarboxylase inhibitor on tetragastrin treatment of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in wistar rats
✍ Masaharu Tatsuta; Hiroyasu Iishi; Miyako Baba; Haruo Taniguchi 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 French ⚖ 474 KB 👁 1 views

The effects of combined administration of tetragastrin and the ornithine decarboxylase inhibitor I ,)-diaminopropane (DAP) on the incidence and number of gastric cancers induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), and the BUdR labelling indices of the fundic and antral mucosae, were inve

Effects of bilateral and unilateral vago
Effects of bilateral and unilateral vagotomy on gastric carcinogenesis induced by N-methyl-N′-nitro-N-nitrosoguanidine in wistar rats
✍ Masaharu Tatsuta; Hiroyasu Iishi; Hisako Yamamura; Miyako Baba; Haruo Taniguchi 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 French ⚖ 570 KB

After administration of N-methyl-N'-nitro-N-nitrosoguanidine for I5 weeks, the effects of bilateral, anterior and posterior vagotomy on the incidence, number and location of gastric adenocarcinomas, gastric acid secretion and cell proliferation of the gastric mucosa were investigated in inbred Wista

Attenuating effect of ornithine decarbox
Attenuating effect of ornithine decarboxylase inhibitor (1,3-diaminopropane) on bombesin enhancement of gastric carcinogenesis induced by N-methyl-N'-nitro-N- nitrosoguanidine
✍ Hiroyasu Iishi; Masaharu Tatsuta; Miyako Baba; Shigeru Okuda; Haruo Taniguchi 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 French ⚖ 491 KB 👁 1 views

## Abstract The effects of combined administration of bombesin and the ornithine decarboxylase (ODC) inhibitor 1,3‐diaminopropane (DAP) on the incidence and number of gastric tumors induced by N‐methyl‐N'‐nitro‐N‐nitrosoguanidine (MNNG), the ODC activity of the gastric wall and the labelling index