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Attenuated familial adenomatous polyposis due to a mutation in the 3′ part of the APC gene. A clue for understanding the function of the APC protein

✍ Scribed by W. Friedl,S. Meuschel,C. Lamberti,M. Sengteller,P. Propping…

Book ID: 118291995
Publisher: Springer
Year: 1996
Tongue: English
Weight: 108 KB
Volume: 97
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf02281864

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## Abstract Familial adenomatous polyposis (FAP) is an autosomal dominant syndrome predisposing to colorectal cancer and affects 1 in 5–10,000 births. Inheritance of a mutant allele of the adenomatous polyposis coli (__APC__) gene is the cause of ∼80% of FAP and 20–30% of an attenuated form of FAP