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Atropisomeric 3-(β-hydroxyethyl)-4-arylquinolin-2-ones as Maxi-K Potassium Channel Openers

✍ Scribed by Vrudhula, Vivekananda M.; Dasgupta, Bireshwar; Qian-Cutrone, Jingfang; Kozlowski, Edward S.; Boissard, Christopher G.; Dworetzky, Steven I.; Wu, Dedong; Gao, Qi; Kimura, Roy; Gribkoff, Valentin K.; Starrett, John E.


Book ID
126323507
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
128 KB
Volume
50
Category
Article
ISSN
0022-2623

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✍ BÉNÉDicte Erb; Rufine Akue; Benoît Rigo; Bernard Pirotte; Daniel Couturier 📂 Article 📅 2000 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 486 KB

## Abstract Starting from 2‐thioxoquinazolin‐4‐one, the synthesis of 2‐amino‐4(3__H__)‐one derivatives, structurally related to potassium channels openers pinacidil and diazoxide, is described.