ATR and ATM regulate the timing of DNA replication origin firing
β Scribed by Shechter, David; Costanzo, Vincenzo; Gautier, Jean
- Book ID
- 109912272
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 954 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1465-7392
- DOI
- 10.1038/ncb1145
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## Abstract The piRNA class of small RNAs are distinct from other small RNAs by their βΌ26β31 nucleotide size, singleβstrandedness and strandβspecificity as well as by the clustered arrangement of their origins. Here, we highlight how these features are reminiscent of the mechanisms of DNA replicati
## Abstract Genomic propagation in both prokaryotes and eukaryotes is tightly regulated at the level of initiation, ensuring that the genome is accurately replicated and equally segregated to the daughter cells. Even though replication origins and the proteins that bind onto them (initiator protein