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Atorvastatin, an HMG-COA reductase inhibitor and effective lipid-regulating agent. Part III. Syntheses of [2H5]-, [13C8], and [13C7,15N]atorvastatin and their application in metabolic and pharmacokinetic studies

โœ Scribed by Peter W. K. Woo; Jon Hartman; James Hicks; Roger Hayes


Publisher
John Wiley and Sons
Year
1999
Tongue
French
Weight
637 KB
Volume
42
Category
Article
ISSN
0022-2135

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Atorvastatin, an HMG-COA reductase inhib
โœ Peter W. K. Woo; Jon Hartman; Yun Huang; Thomas Nanninga; Kelvin Bauman; Donald ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 461 KB ๐Ÿ‘ 2 views

SUMMARY Pyrrole-ring labeled \(\left[{ }^{14} \mathrm{C}\right]\) atorvastatin (Lipitor 8 , CI-981), [ \(\left.\mathrm{R}-\left(\mathrm{R}^{*}, \mathrm{R}^{*}\right)\right]-2-\) (4-fluorophenyl)- \(\beta, \gamma\)-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-[3- \(\left.{ }^{14}