Atorvastatin, an HMG-COA reductase inhibitor and effective lipid-regulating agent. Part II. Synthesis of side-chain-labeled [14C]atorvastatin

Atorvastatin, an HMG-COA reductase inhib

Atorvastatin, an HMG-COA reductase inhibitor and efficient lipid-regulating agent. Part I. Synthesis of ring-labeled [14C6]atorvastatin

✍ Peter W. K. Woo; Jon Hartman; Yun Huang; Thomas Nanninga; Kelvin Bauman; Donald 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 461 KB 👁 1 views

SUMMARY Pyrrole-ring labeled \(\left[{ }^{14} \mathrm{C}\right]\) atorvastatin (Lipitor 8 , CI-981), [ \(\left.\mathrm{R}-\left(\mathrm{R}^{*}, \mathrm{R}^{*}\right)\right]-2-\) (4-fluorophenyl)- \(\beta, \gamma\)-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-[3- \(\left.{ }^{14}