✦ LIBER ✦

Atopic dermatitis: Review of immunopathogenesis and advances in immunosuppressive therapy

✍ Scribed by Linton J Meagher; Nina Y Wines; Alan J Cooper

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 142 KB
Volume: 43
Category: Article
ISSN: 0004-8380
DOI: 10.1046/j.1440-0960.2002.00610.x

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✦ Synopsis

SUMMARY

This paper reviews the theories of the pathogenesis of atopic dermatitis (AD), with a particular emphasis on its immunopathogenesis. The contribution of predisposing factors, immunopathogenic factors and provoking factors in the pathogenesis of AD are considered. Predisposing factors explored in this article include genetics and the disturbance of skin function. Immunopathogenic factors reviewed include T cell dysfunction, biphasic cytokine expression and the role of immunoglobulin E. Provoking factors considered include microbial factors, psychosomatic interactions, contact allergens and irritants, inhalant allergens, food and climate. Immunosuppressive treatments reviewed include cyclosporin, azathioprine, methotrexate, tacrolimus, interferon‐γ, phosphodiesterase inhibitors and pimecrolimus (SDZ ASM 981).

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