Neoadjuvant chemotherapy in the treatment of locally advanced cervical carcinoma in pregnancy : A report of two cases and review of issues specific to the management of cervical carcinoma in pregnancy including planned delay of therapy

✍ Scribed by Krishnansu Tewari; Fabio Cappuccini; Angela Gambino; Matthew F. Kohler; Sergio Pecorelli; Philip J. DiSaia

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 146 KB
• Volume: 82
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/(sici)1097-0142(19980415)82:8<1529::aid-cncr15>3.0.co;2-6

✦ Synopsis

underwent delivery and definitive surgical treatment. The patients were evaluated of Obstetrics and Gynecology, University of Calduring pregnancy for evidence of a clinical response to chemotherapy. Intraopera-ifornia-Irvine Medical Center, Orange, California.

tive findings and pathologic analysis of the surgical material provided further objec-2 Division of Gynecologic Oncology, University tive data regarding disease status. of Brescia, Brescia, Italy.

RESULTS.

Both patients experienced a dramatic reduction in tumor volume, rendering radical hysterectomy feasible at the time of cesarean section. In addition, both patients tolerated chemotherapy well and there were no adverse fetal effects.

Favorable neonatal outcomes were achieved. One patient experienced recurrence within 5 months of surgery, whereas the other patient remained without evidence of disease for 2 years.

CONCLUSIONS.

To the authors' knowledge, these reports constitute the first description of the use of neoadjuvant chemotherapy for invasive squamous cell carcinoma of the cervix in pregnancy (MEDLINE 1966-1997). This therapeutic option should be considered in selected women with locally advanced cervical carcinoma who do not want termination of their pregnancy.