✦ LIBER ✦

Atomic force microscopy used for the surface characterization of microcapsule immunoisolation devices

✍ Scribed by Xu, Keyang ;Hercules, David M. ;Lacik, Igor ;Wang, Taylor G.

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 657 KB
Volume: 41
Category: Article
ISSN: 0021-9304
DOI: 10.1002/(sici)1097-4636(19980905)41:3<461::aid-jbm16>3.0.co;2-l

No coin nor oath required. For personal study only.

✦ Synopsis

The surface morphology of the microcapsule used as a bioartificial pancreas was examined by atomic force microscopy (AFM) under ambient conditions in a liquid environment. The standard contact mode was used for imaging. The capsules exhibited different morphologies and surface roughness depending on the composition of the cation solution: namely, the mole ratio of antigelling and gelling cations [Na + ]/[Ca 2+ ]. Surface roughness parameters obtained by AFM measurements provide quantitative informa-tion on the surface properties of the capsular membrane. In this respect, AFM can be considered a valuable technique complementary to optical microscopy in providing feedback for capsule optimization.

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