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ATM–the first step in helping cells deal with DNA damage

✍ Scribed by M.B. Kastan

Book ID
117575592
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
33 KB
Volume
58
Category
Article
ISSN
0753-3322

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## Abstract After irradiation, ATM defective cells accumulate unrepaired double strand breaks (DSBs) for several cell divisions. At the chromosome level, unresolved DSBs appear as chromosome breaks that can be efficiently scored by using telomeric and mFISH probes. H2AX is immediately activated by