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No attenuation of the ATM-dependent DNA damage response in murine telomerase-deficient cells

✍ Scribed by Natalie Erdmann; Lea A. Harrington


Book ID
113568050
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
745 KB
Volume
8
Category
Article
ISSN
1568-7864

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✍ Marta MartΓ­n; Mariona Terradas; George Iliakis; Laura Tusell; Anna GenescΓ  πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 870 KB

## Abstract After irradiation, ATM defective cells accumulate unrepaired double strand breaks (DSBs) for several cell divisions. At the chromosome level, unresolved DSBs appear as chromosome breaks that can be efficiently scored by using telomeric and mFISH probes. H2AX is immediately activated by