The ATM gene variants segregating in ataxia-telangiectasia families are associated with increased breast cancer risk, but the contribution of specific variants has been difficult to estimate. Previous small studies suggested two functional variants, c.7271T>G and c.1066-6T>G (IVS10-6T>G), are associ
ATM variants 7271T>G and IVS10-6T>G among women with unilateral and bilateral breast cancer
✍ Scribed by Bernstein, J L; Bernstein, L; Thompson, W D; Lynch, C F; Malone, K E; Teitelbaum, S L; Olsen, J H; Anton-Culver, H; Boice, J D; Rosenstein, B S; Børresen-Dale, A-L; Gatti, R A; Concannon, P; Haile, R W
- Book ID
- 121840809
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 87 KB
- Volume
- 89
- Category
- Article
- ISSN
- 0007-0920
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Patients with autosomal recessive multisystemic disorder ataxia-telangiectasia are homozygous or compound heterozygous for mutations in the ataxia-telangiectasia mutated (ATM) gene. Heterozygous carriers of an ATM germline mutation have an increased susceptibility for breast cancer. The subject of t
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