The ATM gene variants segregating in ataxia-telangiectasia families are associated with increased breast cancer risk, but the contribution of specific variants has been difficult to estimate. Previous small studies suggested two functional variants, c.7271T>G and c.1066-6T>G (IVS10-6T>G), are associ
On the proposed association of the ATM variants 5557G>A and IVS38-8T>C and bilateral breast cancer
✍ Scribed by Bryan Langholz; Jonine L. Bernstein; Leslie Bernstein; Jørgen H. Olsen; Anne-Lise Børresen-Dale; Barry S. Rosenstein; Richard A. Gatti; The WECARE Study Collaborative Group; Patrick Concannon
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- French
- Weight
- 54 KB
- Volume
- 119
- Category
- Article
- ISSN
- 0020-7136
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## Communicated by Richard Wooster Homozygous mutation in the ATM gene causes ataxia telangiectasia and heterozygous mutation carriers may be at increased risk of breast cancer. We studied a total of 22 ATM variants; 18 variants were analyzed in one of two large population-based studies from the U
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