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At least two different regions are involved in allelic imbalance on chromosome 16q in breast cancer

✍ Scribed by Anne-Marie Cleton-Jansen; Elna W. Moerland; Nel J. Kuipers-Dijkshoorn; David C. Callen; Grant R. Sutherland; Peter Devilee; Cees J. Cornelisse

Book ID
119106291
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
92 KB
Volume
77
Category
Article
ISSN
0165-4608

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At least two different regions are invol
At least two different regions are involved in allelic imbalance on chromosome arm 16q in breast cancer
✍ Dr. Anne-Marie Cleton-Jansen; Elna W. Moerland; Net J. Kuipers-Dijkshoorn; Cees πŸ“‚ Article πŸ“… 1994 πŸ› John Wiley and Sons 🌐 English βš– 565 KB

## Abstract Loss of heterozygosity (LOH) or allelic imbalance, the latter term referring to both loss and gain of an allele, on the long arm of chromosome 16 has been repeatedly found in cancers of, e.g., the breast and prostate. This indicates the presence of one or more tumor suppressor genes on

Identification of two distinct regions o
Identification of two distinct regions of allelic imbalance on chromosome 18q in metastatic prostate cancer
✍ Susan S. Padalecki; Dean A. Troyer; Marc F. Hansen; Tomo Saric; Barbara G. Schne πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 French βš– 115 KB πŸ‘ 2 views

Like most cancers, prostate cancer (CaP) is believed to be the result of the accumulation of genetic alterations within cells. Previous studies have implicated numerous chromosomal regions with elevated rates of allelic imbalance (AI), using mostly primary CaPs with an unknown disease outcome. These

High frequency of allelic imbalance at c
High frequency of allelic imbalance at chromosome region 16q22-23 in human breast cancer: Correlation with high pgr and low s phase
✍ Sigurlaug Skirnisdottir; Gudny Eiriksdottir; Trausti Baldursson; Rosa B. Barkard πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 French βš– 668 KB

The loss of genetic material from a specific chromosome region in tumors suggests the presence of tumor-suppressor genes. Loss of heterozygosity (LOH) or allelic imbalance (Al) on the long arm of chromosome 16 is a known event in sporadic breast cancer. To locate the commonly deleted regions, and th