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Asynchronous replication and allelic exclusion in the immune system

✍ Scribed by Singh, Nandita; Tenzen, Toyoaki; Goldmit, Maya; Gabay, Chana; Elizur, Sharon; Qi, Peimin; Reubinoff, Benjamin E.; Chess, Andrew; Cedar, Howard; Mostoslavsky, Raul

Book ID
109776526
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
221 KB
Volume
414
Category
Article
ISSN
0028-0836

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## Abstract To prevent duplicate DNA synthesis, metazoan replication origins are licensed during G1. Only licensed origins can initiate replication, and the cytoplasm interacts with the nucleus to inhibit new licensing during S phase. DNA replication in the mammalian one‐cell embryo is unique becau