Asymmetric α-amination reaction of alkenyl trifluoroacetates catalyzed by a chiral phosphine–silver complex
✍ Scribed by Yanagisawa, Akira; Miyake, Ryoji; Yoshida, Kazuhiro
- Book ID
- 125497063
- Publisher
- Royal Society of Chemistry
- Year
- 2014
- Tongue
- English
- Weight
- 326 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1477-0520
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Aldol reaction of N,N-dialkyl-a-isocyanoacetamides with primary alkyl aldehydes in the presence of 0.5-l mol% OF a chiral (aminoalkyl)ferrocenylphosphine-gold(I) catalyst proceeded with high enantio-and diastereoselectivity to give trans-5-alkyl-2-oxazoline-4-carboxamides of up to 98.6% ee, which we