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Asymmetric aldol reaction of α-isocyanoacetamides with aldehydes catalyzed by a chiral ferrocenylphosphine-gold(I) complex

✍ Scribed by Yoshihiko Ito; Masaya Sawamura; Masaaki Kobayashi; Tamio Hayashi

Publisher
Elsevier Science
Year
1988
Tongue
French
Weight
237 KB
Volume
29
Category
Article
ISSN
0040-4039

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✦ Synopsis

Aldol reaction of N,N-dialkyl-a-isocyanoacetamides with primary alkyl aldehydes in the presence of 0.5-l mol% OF a chiral (aminoalkyl)ferrocenylphosphine-gold(I) catalyst proceeded with high enantio-and diastereoselectivity to give trans-5-alkyl-2-oxazoline-4-carboxamides of up to 98.6% ee, which were converted into optically active threo-B-hydroxyamino acids.

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