Asymmetric Vinylogous Mukaiyama Aldol Reaction
β Scribed by Markus Kalesse; Jorma Hassfeld
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 11 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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π SIMILAR VOLUMES
## Abstract The reaction is promoted by oxazaborolidinones (I) with derivative (Ia) providing the products with mostly higher enantioselectivity.
## Abstract The present new disulfonimide catalyzed vinylogous Mukaiyama aldol addition of crotonic acid derivatives (I) to aldehydes can also be applied to ketene acetal nucleophiles (IV).
## Abstract Vinylogous Mukaiyamaβtype aldol reactions have been catalyzed by a combination of Cu(OTf)~2~ and readily available __C__~1~βsymmetric aminosulfoximines. After a fineβtuning of the reaction conditions and an optimization of the modularly assembled ligand structure, high stereoselectiviti