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Asymmetric Transfer Hydrogenation of α-Aminoalkyl α‘-Chloromethyl Ketones with Chiral Rh Complexes

✍ Scribed by Hamada, Takayuki; Torii, Takayoshi; Onishi, Tomoyuki; Izawa, Kunisuke; Ikariya, Takao


Book ID
125498707
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
71 KB
Volume
69
Category
Article
ISSN
0022-3263

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Catalytic asymmetric hydrogenation of α-
✍ Viviane Massonneau; Paul Le Maux; Gerard Simonneaux 📂 Article 📅 1986 🏛 Elsevier Science 🌐 French ⚖ 106 KB

Chiral ruthenium hydrides : HRuCl(TRPC)2 and H2Ru(TBPC)2 catalyse the hydrogenation of a-&unsaturated ketones to ketones (e.e. 62 X). Asymmetric hydrogenation of prochiral olefins in the presence of chiral rhodium catalyst 1 is now a useful preparative tool for many a-aminoacids