Asymmetric total synthesis of (−)-prosophylline
✍ Scribed by Sofia D. Koulocheri; Serkos A. Haroutounian
- Book ID
- 104262169
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 123 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The asymmetric total synthesis of (-)-prosophylline from D-glucal via (2S)-hydroxymethyl-dihydropyridone 6 by a 17-step synthesis and 12% overall yield is presented.
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Asymmetric total synthesis of (+)-desoxoprosophylline 2 from the ~t-furfuryl amine derivative 1 was accomplished via ten steps in an overall yield of 4%. The oxidation of 1 to dihydropyridone 3 was used as the key step.