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Asymmetric Total Synthesis of (-)-Cribrostatin 4 (Renieramycin H).

✍ Scribed by Guillaume Vincent; Robert M. Williams

Publisher
John Wiley and Sons
Year
2007
Weight
15 KB
Volume
38
Category
Article
ISSN
0931-7597

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Total Synthesis of the Marine Natural Pr
Total Synthesis of the Marine Natural Product (βˆ’)-Cribrostatin 4 (Renieramycin H)
✍ Xiaochuan Chen; Jieping Zhu πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 153 KB πŸ‘ 2 views

Scheme 5. Domino cyclization to construct the pentacyclic core of cribrostatin 4 (1): a) n-C 6 H 13 SH, TFA/TFE 1:100, 93 %; b) Swern oxidation; c) TBAF, AcOH, THF; d) MeSO 3 H (0.01 % by volume, c = 0.01 m), CH 2 Cl 2 , 51 % (for 3 steps). TFA = trifluoroacetic acid, TFE = trifluoroethanol.