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Asymmetric Total Synthesis of (−)-Cribrostatin 4 (Renieramycin H)

✍ Scribed by Guillaume Vincent; Robert M. Williams

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
139 KB
Volume
119
Category
Article
ISSN
0044-8249

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Total Synthesis of the Marine Natural Product (−)-Cribrostatin 4 (Renieramycin H)
✍ Xiaochuan Chen; Jieping Zhu 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 153 KB 👁 2 views

Scheme 5. Domino cyclization to construct the pentacyclic core of cribrostatin 4 (1): a) n-C 6 H 13 SH, TFA/TFE 1:100, 93 %; b) Swern oxidation; c) TBAF, AcOH, THF; d) MeSO 3 H (0.01 % by volume, c = 0.01 m), CH 2 Cl 2 , 51 % (for 3 steps). TFA = trifluoroacetic acid, TFE = trifluoroethanol.