Asymmetric synthesis. XXXVI1. Synthesis of tetrahydroazocines by [2+2] thermal cycloaddition to latent 1,4-dihydropyridines
β Scribed by Marie-Christine Lallemand; Mohamed Chiadmi; Alain Tomas; Nicole Kunesch; Henri-Philippe Husson
- Book ID
- 103403715
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 242 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
Absfmct: Benxyne has been generated from benzencdiezonimn-2carboxylate in the presence of several 1,2,4triaxinea 1 snd isoquinolines 2 have been is&ted ia inodeam yield. I-Aminobenarkole was also used as the scurce of benxyne and kxpinolines went again is&ted in mode&e yield from these react&s CMe&y
1 and alkenes 2 with an electron-withdrawing or an electron-donating group 2 a-f and 2 g-h regioselectively yields the 4-substituted and the 3-substituted 2-hydroxy-1,2,3,4\_tetrahydropyridines 3 respectively. Dehydratisation of 3 with electron-withdrawing groups at C-4 gives the 1,4\_dihydropyridin