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Asymmetric synthesis XVII : Facile generation of a chiral azomethine ylide via the CN(R,S) method

✍ Scribed by Jacques Rouden; Jacques Royer; Henri-Philippe Husson


Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
230 KB
Volume
30
Category
Article
ISSN
0040-4039

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Asymmetric synthesis xx preparation of a
✍ Jieping Zhu; Jean-Charles Quirion; Henri-Philippe Husson πŸ“‚ Article πŸ“… 1989 πŸ› Elsevier Science 🌐 French βš– 172 KB

A novel spiropiperidine system i.e an aza structural analog of histrionicotoxin has been constructed from 2-cyano-6-phenyloxazolopiperidine synthon 3. The suitable quaternary carbon was created by alkylation at the position c~ ta the nitrile fallowed by transformation of the nitrile group into a pri