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Asymmetric synthesis XVI. Enantiomerically pure substituted cyclopropane amino acid precursors via the cn(R,S) method

✍ Scribed by David J. Aitken; Jacques Royer; Henri-Philippe Husson


Publisher
Elsevier Science
Year
1988
Tongue
French
Weight
222 KB
Volume
29
Category
Article
ISSN
0040-4039

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πŸ“œ SIMILAR VOLUMES


Asymmetric Syntheses via Heterocyclic In
✍ SchΓΆllkopf, Ulrich ;Bardenhagen, JΓΌrgen πŸ“‚ Article πŸ“… 1987 πŸ› John Wiley and Sons 🌐 English βš– 534 KB

The titanium derivative 4a of the bislactim ether l a from cyclo-(L-Val-Gly) reacts with + m a t u r a t e d aldehydes 5 exclusively by 1.2-addition in a highly diastereowlective mode to give virtually only the (2R,l'S) diastereomers of type 6. Upon hydrolysis these furnish the methyl (2R,3S)-thrm-2