Synthesis of enantiomerically pure (S)-3
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Günter Helmchen; Günter Wegner
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Article
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1985
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Elsevier Science
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French
⚖ 253 KB
+)(S)-3-Trichloromethylbutyric acid, a building block for syntheses of various marine natural products, can be prepared via 99:l stereoselective conjugate addition of C13CMgC1 to the crotonate of a chiral auxiliary containing a sulfonylamino substituent. Recently several polychlorinated metabolites