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Asymmetric synthesis of β-alkoxy substituted phenethylamine analogs

✍ Scribed by George Zaponakis; Haralambos E. Katerinopoulos


Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
156 KB
Volume
37
Category
Article
ISSN
0040-4039

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Efficient asymmetric synthesis of 3-subs
✍ Dieter Enders; Stefan Wallert 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 91 KB

The asymmetric synthesis of 3-substituted 1,2-thiazetidine 1,1-dioxides by cyclization of b-amino-sulfonyl chlorides is reported. The synthesis is based on the aza-Michael addition of (R,R,R)-2-amino-3-methoxymethyl-2-azabicyclo[3.3.0]octane (RAMBO) to alkenyl-sulfonates.