Asymmetric Synthesis of α-Substituted β-Nitrophosphonic Acids by Phospha-Analogous Michael Addition to Aromatic Nitroalkenes
✍ Scribed by Dieter Enders; Livio Tedeschi; Jan Willem Bats
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 89 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0044-8249
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The aza-Michael addition of enantiopure 1-aminopyrrolidines to (E)-alkenyl sulfones in the presence of a catalytic amount of ytterbium trifluoromethanesulfonate [Yb(OTf) 3 ] yields β-hydrazino sulfones in moderate to good yields and with diastereoselectivities of up to 98%. The latter undergo reduct