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Asymmetric Synthesis of β 2 -Tryptophan Analogues via Friedel–Crafts Alkylation of Indoles with a Chiral Nitroacrylate

✍ Scribed by Pavlov, Nikola; Gilles, Pierre; Didierjean, Claude; Wenger, Emmanuel; Naydenova, Emilia; Martinez, Jean; Calmès, Monique


Book ID
127146335
Publisher
American Chemical Society
Year
2011
Tongue
English
Weight
991 KB
Volume
76
Category
Article
ISSN
0022-3263

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## Abstract The Friedel‐Crafts alkylation of indoles with nitroacrylates could provide __α__‐ and __β__‐tryptophan nitro‐precursors, respectively, in moderate to good yields under Lewis acid catalysis. The diastereoselectivities of the reaction were enhanced by using 2‐substituted indoles. The alky