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Catalytic and Asymmetric Friedel—Crafts Alkylation of Indoles with Nitroacrylates. Application to the Synthesis of Tryptophan Analogues.

✍ Scribed by Yong Sui; Li Liu; Jun-Ling Zhao; Dong Wang; Yong-Jun Chen


Publisher
John Wiley and Sons
Year
2007
Weight
45 KB
Volume
38
Category
Article
ISSN
0931-7597

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## Abstract The Friedel‐Crafts alkylation of indoles with nitroacrylates could provide __α__‐ and __β__‐tryptophan nitro‐precursors, respectively, in moderate to good yields under Lewis acid catalysis. The diastereoselectivities of the reaction were enhanced by using 2‐substituted indoles. The alky