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Asymmetric Synthesis of the Potent HIV-Protease Inhibitor, Nelfinavir

โœ Scribed by Raghavan, Sadagopan; Krishnaiah, V.; Sridhar, B.


Book ID
118066729
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
957 KB
Volume
75
Category
Article
ISSN
0022-3263

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A synthesis of the HIV-protease inhibito
โœ Kim F Albizati; Srinivasan Babu; Angela Birchler; Juliette K Busse; Michelle Fug ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 80 KB

This letter describes a new synthesis of the HIV-protease inhibitor nelfinavir. The synthesis features a selective opening of a D-tartaric acid-derived cyclic sulfate with nitrogen nucleophiles.