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Asymmetric Synthesis of the Polyol Subunit (I) of the Macrolide Antibiotic, Ossamycin (II).

โœ Scribed by Noriki Kutsumura; Shigeru Nishiyama


Publisher
John Wiley and Sons
Year
2005
Weight
15 KB
Volume
36
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Synthesis of Amphot
โœ G. J. MCGARVEY; J. A. MATHYS; K. J. WILSON ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 33 KB ๐Ÿ‘ 1 views

Synthesis of Amphotericin B, a Convergent Strategy to the Polyol Segment of the Heptaene Macrolide Antibiotics. -The key step in the synthesis of the ester (VIII), a potent precursor of amphotericin B, is stereoselective cycloaddition of the dipolarophile (III) to the nitrile oxide generated from t